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MiRNA-21 mediates the antiangiogenic activity of metformin through targeting PTEN and SMAD7 expression and PI3K/AKT pathway

Metformin, an anti-diabetic drug commonly used for type 2 diabetes therapy, is associated with anti-angiogenic effects in conditions beyond diabetes. miR-21 has been reported to be involved in the process of angiogenesis. However, the precise regulatory mechanisms by which the metformin-induced endo...

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Detalhes bibliográficos
Publicado no:Sci Rep
Principais autores: Luo, Mao, Tan, Xiaoyong, Mu, Lin, Luo, Yulin, Li, Rong, Deng, Xin, Chen, Ni, Ren, Meiping, Li, Yongjie, Wang, Liqun, Wu, Jianbo, Wan, Qin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322530/
https://ncbi.nlm.nih.gov/pubmed/28230206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43427
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