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Endothelin receptor-specific control of endoplasmic reticulum stress and apoptosis in the kidney

Endothelin-1 (ET-1) promotes renal damage during cardiovascular disease; yet, the molecular mechanisms involved remain unknown. Endoplasmic reticulum (ER) stress, triggered by unfolded protein accumulation in the ER, contributes to apoptosis and organ injury. These studies aimed to determine whether...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: De Miguel, Carmen, Hamrick, William C., Hobbs, Janet L., Pollock, David M., Carmines, Pamela K., Pollock, Jennifer S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322462/
https://ncbi.nlm.nih.gov/pubmed/28230089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43152
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