Silencing CAPN2 Expression Inhibited Castration-Resistant Prostate Cancer Cells Proliferation and Invasion via AKT/mTOR Signal Pathway

The mRNA expression of CAPN2 was upregulated in CRPC cells (DU145 and PC3) than that in non-CRPC cells. Silencing CAPN2 expression could inhibit DU145 and PC3 cells proliferation by cell cycle arrest at G1 phase. Knockdown of CPAN2 level suppressed the migration and invasion capacity of CRPC cells b...

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Detalles Bibliográficos
Publicado en:Biomed Res Int
Autores principales: Li, Pu, Miao, Chenkui, Liang, Chao, Shao, Pengfei, Wang, Zengjun, Li, Jie
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322456/
https://ncbi.nlm.nih.gov/pubmed/28280729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/2593674
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