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Optogenetic activation of VGLUT2-expressing excitatory neurons blocks epileptic seizure-like activity in the mouse entorhinal cortex

We investigated whether an anti-epileptic effect is obtained by selectively activating excitatory neurons expressing ChR2 under the promoter for the synaptic vesicular glutamate transporter 2 (VGLUT2). VGLUT2-expressing cells were optically stimulated while local field potential and whole-cell patch...

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Publicado en:Sci Rep
Autores principales: Yekhlef, Latefa, Breschi, Gian Luca, Taverna, Stefano
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322365/
https://ncbi.nlm.nih.gov/pubmed/28230208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43230
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