T-Cells Specific for a Self-Peptide of ApoB-100 Exacerbate Aortic Atheroma in Murine Atherosclerosis

On the basis of mouse I-A(b)-binding motifs, two sequences of the murine apolipoprotein B-100 (mApoB-100), mApoB-100(3501–3515) (designated P3) and mApoB-100(978–992) (designated P6), were found to be immunogenic. In this report, we show that P6 is also atherogenic. Immunization of Apoe(−/−) mice fe...

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Udgivet i:Front Immunol
Main Authors: Shaw, Michael K., Tse, Kevin Y., Zhao, Xiaoqing, Welch, Kathryn, Eitzman, Daniel T., Thipparthi, Raghavendar R., Montgomery, Paul C., Thummel, Ryan, Tse, Harley Y.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322236/
https://ncbi.nlm.nih.gov/pubmed/28280493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00095
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