Influence of the hinge region on complement activation, C1q binding, and segmental flexibility in chimeric human immunoglobulins.

We have characterized a series of genetically engineered chimeric human IgG3 and IgG4 anti-dansyl (DNS) antibodies with identical antibody-combining sites but different hinge region amino acid compositions to determine how the hinge region influences Fab fragment segmental flexibility, C1q binding,...

Полное описание

Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Tan, L K, Shopes, R J, Oi, V T, Morrison, S L
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1990
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53220/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2296577/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.1.162
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