Arylmethylamino steroids as antiparasitic agents

In search of antiparasitic agents, we here identify arylmethylamino steroids as potent compounds and characterize more than 60 derivatives. The lead compound 1o is fast acting and highly active against intraerythrocytic stages of chloroquine-sensitive and resistant Plasmodium falciparum parasites (I...

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Publicado no:Nat Commun
Main Authors: Krieg, Reimar, Jortzik, Esther, Goetz, Alice-Anne, Blandin, Stéphanie, Wittlin, Sergio, Elhabiri, Mourad, Rahbari, Mahsa, Nuryyeva, Selbi, Voigt, Kerstin, Dahse, Hans-Martin, Brakhage, Axel, Beckmann, Svenja, Quack, Thomas, Grevelding, Christoph G., Pinkerton, Anthony B., Schönecker, Bruno, Burrows, Jeremy, Davioud-Charvet, Elisabeth, Rahlfs, Stefan, Becker, Katja
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321741/
https://ncbi.nlm.nih.gov/pubmed/28211535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14478
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