BRAF Mutation Correlates With High-Risk Langerhans Cell Histiocytosis and Increased Resistance to First-Line Therapy

PURPOSE: Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia with a broad spectrum of clinical manifestations and outcomes in children. The somatic BRAF(V600E) mutation occurs frequently, but clinical significance remains to be determined. PATIENTS AND METHODS: BRAF(V600E) mutat...

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Publicat a:J Clin Oncol
Autors principals: Héritier, Sébastien, Emile, Jean-François, Barkaoui, Mohamed-Aziz, Thomas, Caroline, Fraitag, Sylvie, Boudjemaa, Sabah, Renaud, Florence, Moreau, Anne, Peuchmaur, Michel, Chassagne-Clément, Catherine, Dijoud, Frédérique, Rigau, Valérie, Moshous, Despina, Lambilliotte, Anne, Mazingue, Françoise, Kebaili, Kamila, Miron, Jean, Jeziorski, Eric, Plat, Geneviève, Aladjidi, Nathalie, Ferster, Alina, Pacquement, Hélène, Galambrun, Claire, Brugières, Laurence, Leverger, Guy, Mansuy, Ludovic, Paillard, Catherine, Deville, Anne, Armari-Alla, Corinne, Lutun, Anne, Gillibert-Yvert, Marion, Stephan, Jean-Louis, Cohen-Aubart, Fleur, Haroche, Julien, Pellier, Isabelle, Millot, Frédéric, Lescoeur, Brigitte, Gandemer, Virginie, Bodemer, Christine, Lacave, Roger, Hélias-Rodzewicz, Zofia, Taly, Valérie, Geissmann, Frédéric, Donadieu, Jean
Format: Artigo
Idioma:Inglês
Publicat: American Society of Clinical Oncology 2016
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ORIGINAL REPORTS
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321082/
https://ncbi.nlm.nih.gov/pubmed/27382093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2015.65.9508
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