Novel aromatase inhibitors selection using induced fit docking and extra precision methods: Potential clinical use in ER-alpha-positive breast cancer

Aromatase (CYP19A1) the key enzyme of estrogen biosynthesis, is often deregulated in breast cancer patients. It catalyzes the conversion of androgen to estrogen, thus responsible for production of estrogen in human body. However, it causes over-production of estrogen which eventually leads to prolif...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Bioinformation
Egile Nagusiak: Kumavath, Ranjith, Azad, Manan, Devarapalli, Pratap, Tiwari, Sandeep, Kar, Shreya, Barh, Debmalya, Azevedo, Vasco, Kumar, Alan Prem
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Biomedical Informatics 2016
Gaiak:
Hypothesis
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320928/
https://ncbi.nlm.nih.gov/pubmed/28293075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.6026/97320630012324
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