Sample size considerations for trials using cerebral white matter hyperintensity progression as an intermediate outcome at 1 year after mild stroke: results of a prospective cohort study

BACKGROUND: White matter hyperintensities (WMHs) are commonly seen on in brain imaging and are associated with stroke and cognitive decline. Therefore, they may provide a relevant intermediate outcome in clinical trials. WMH can be measured as a volume or visually on the Fazekas scale. We investigat...

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Detalhes bibliográficos
Publicado no:Trials
Main Authors: Chappell, Francesca M., del Carmen Valdés Hernández, Maria, Makin, Stephen D., Shuler, Kirsten, Sakka, Eleni, Dennis, Martin S., Armitage, Paul A., Muñoz Maniega, Susana, Wardlaw, Joanna M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320698/
https://ncbi.nlm.nih.gov/pubmed/28222778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-017-1825-7
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