Integrative genomics analysis identifies ancestral-related eQTLs on POLB, and supports the association of genetic ancestry with survival disparity in HNSCC

BACKGROUND: African-Americans (Afr-Amr) with head and neck squamous cell carcinoma (HNSCC) have a lower survival rate than Caucasians (Cau). This study investigates the functional importance of ancestry-informative SNPs in HNSCC and also examines the effect of functionally important genetic elements...

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Veröffentlicht in:Cancer
Hauptverfasser: Ramakodi, Meganathan P., Devarajan, Karthik, Blackman, Elizabeth, Gibbs, Denise, Luce, Danièle, Deloumeaux, Jacqueline, Duflo, Suzy, Liu, Jeffrey C., Mehra, Ranee, Kulathinal, Rob J., Ragin, Camille C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319896/
https://ncbi.nlm.nih.gov/pubmed/27906459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30457
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