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De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFβ-deficient squamous cell carcinoma from transition zones

Squamous cell carcinomas occurring at transition zones are highly malignant tumors with poor prognosis. The identity of the cell population and the signaling pathways involved in the progression of transition zone squamous cell carcinoma are poorly understood, hence representing limited options for...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: McCauley, Heather A, Chevrier, Véronique, Birnbaum, Daniel, Guasch, Géraldine
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319840/
https://ncbi.nlm.nih.gov/pubmed/28219480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22914
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