Dexmedetomidine preconditioning may attenuate myocardial ischemia/reperfusion injury by down-regulating the HMGB1-TLR4-MyD88-NF-кB signaling pathway

AIMS: To investigate whether dexmedetomidine (DEX) preconditioning could alleviate the inflammation caused by myocardial ischemia/reperfusion (I/R) injury by reducing HMGB1-TLR4-MyD88-NF-кB signaling. METHODS: Seventy rats were randomly assigned into five groups: sham group, myocardial I/R group (I/...

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Pubblicato in:PLoS One
Autori principali: Zhang, Jing-jing, Peng, Ke, Zhang, Juan, Meng, Xiao-wen, Ji, Fu-hai
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319750/
https://ncbi.nlm.nih.gov/pubmed/28222157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172006
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