Elimination of the Unnecessary: Intra- and Extracellular Signaling by Anionic Phospholipids

High fidelity of biological systems is frequently achieved by duplication of the essential intracellular machineries or, removal of the entire cell, which becomes unnecessary or even harmful in altered physiological environments. Carefully controlled removal of these cells, without damaging normal c...

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Publicado no:Biochem Biophys Res Commun
Main Authors: Kagan, Valerian E., Bayir, Hülya, Tyurina, Yulia Y., Bolevich, Sergey B., Maguire, John J., Fadeel, Bengt, Balasubramanian, Krishnakumar
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319735/
https://ncbi.nlm.nih.gov/pubmed/28212735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2016.11.005
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spelling pubmed-53197352018-02-03 Elimination of the Unnecessary: Intra- and Extracellular Signaling by Anionic Phospholipids Kagan, Valerian E. Bayir, Hülya Tyurina, Yulia Y. Bolevich, Sergey B. Maguire, John J. Fadeel, Bengt Balasubramanian, Krishnakumar Biochem Biophys Res Commun Article High fidelity of biological systems is frequently achieved by duplication of the essential intracellular machineries or, removal of the entire cell, which becomes unnecessary or even harmful in altered physiological environments. Carefully controlled removal of these cells, without damaging normal cells, requires precise signaling, and is critical to maintaining homeostasis. This review describes how two anionic phospholipids - phosphatidylserine (PS) and cardiolipin (CL) - residing in distinct compartments of the cell, signal removal of ”the unnecessary” using several uniform principles. One of these principles is realized by collapse of inherent transmembrane asymmetry and the externalization of the signal on the outer membrane surface - mitochondria for CL and the plasma membrane for PS – to trigger mitophagy and phagocytosis, respectively. Release from damaged cells of intracellular structures with externalized CL or externalized PS triggers their elimination by phagocytosis. Another of these principles is realized by oxidation of polyunsaturated species of CL and PS. Highly specific oxidation of CL by cytochrome c serves as a signal for mitochondria-dependent apoptosis, while oxidation of externalized PS improves its effectiveness to trigger phagocytosis of effete cells. 2017-02-03 2017-01-15 /pmc/articles/PMC5319735/ /pubmed/28212735 http://dx.doi.org/10.1016/j.bbrc.2016.11.005 Text en
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Article
spellingShingle Article
Kagan, Valerian E.
Bayir, Hülya
Tyurina, Yulia Y.
Bolevich, Sergey B.
Maguire, John J.
Fadeel, Bengt
Balasubramanian, Krishnakumar
Elimination of the Unnecessary: Intra- and Extracellular Signaling by Anionic Phospholipids
description High fidelity of biological systems is frequently achieved by duplication of the essential intracellular machineries or, removal of the entire cell, which becomes unnecessary or even harmful in altered physiological environments. Carefully controlled removal of these cells, without damaging normal cells, requires precise signaling, and is critical to maintaining homeostasis. This review describes how two anionic phospholipids - phosphatidylserine (PS) and cardiolipin (CL) - residing in distinct compartments of the cell, signal removal of ”the unnecessary” using several uniform principles. One of these principles is realized by collapse of inherent transmembrane asymmetry and the externalization of the signal on the outer membrane surface - mitochondria for CL and the plasma membrane for PS – to trigger mitophagy and phagocytosis, respectively. Release from damaged cells of intracellular structures with externalized CL or externalized PS triggers their elimination by phagocytosis. Another of these principles is realized by oxidation of polyunsaturated species of CL and PS. Highly specific oxidation of CL by cytochrome c serves as a signal for mitochondria-dependent apoptosis, while oxidation of externalized PS improves its effectiveness to trigger phagocytosis of effete cells.
author Kagan, Valerian E.
Bayir, Hülya
Tyurina, Yulia Y.
Bolevich, Sergey B.
Maguire, John J.
Fadeel, Bengt
Balasubramanian, Krishnakumar
author_facet Kagan, Valerian E.
Bayir, Hülya
Tyurina, Yulia Y.
Bolevich, Sergey B.
Maguire, John J.
Fadeel, Bengt
Balasubramanian, Krishnakumar
author_sort Kagan, Valerian E.
title Elimination of the Unnecessary: Intra- and Extracellular Signaling by Anionic Phospholipids
title_short Elimination of the Unnecessary: Intra- and Extracellular Signaling by Anionic Phospholipids
title_full Elimination of the Unnecessary: Intra- and Extracellular Signaling by Anionic Phospholipids
title_fullStr Elimination of the Unnecessary: Intra- and Extracellular Signaling by Anionic Phospholipids
title_full_unstemmed Elimination of the Unnecessary: Intra- and Extracellular Signaling by Anionic Phospholipids
title_sort elimination of the unnecessary: intra- and extracellular signaling by anionic phospholipids
container_title Biochem Biophys Res Commun
publishDate 2017
url https://ncbi.nlm.nih.gov/pmc/articles/PMC5319735/
https://ncbi.nlm.nih.gov/pubmed/28212735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2016.11.005
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