Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation

GLUT4 in muscle and adipose tissue is important in maintaining glucose homeostasis. However, the role of insulin-responsive GLUT4 in the central nervous system has not been well characterized. To assess its importance, a selective knockout of brain GLUT4 (BG4KO) was generated by crossing Nestin-Cre...

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Bibliographic Details
Published in:Diabetes
Main Authors: Reno, Candace M., Puente, Erwin C., Sheng, Zhenyu, Daphna-Iken, Dorit, Bree, Adam J., Routh, Vanessa H., Kahn, Barbara B., Fisher, Simon J.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2017
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319720/
https://ncbi.nlm.nih.gov/pubmed/27797912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0917
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