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Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation

GLUT4 in muscle and adipose tissue is important in maintaining glucose homeostasis. However, the role of insulin-responsive GLUT4 in the central nervous system has not been well characterized. To assess its importance, a selective knockout of brain GLUT4 (BG4KO) was generated by crossing Nestin-Cre...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Reno, Candace M., Puente, Erwin C., Sheng, Zhenyu, Daphna-Iken, Dorit, Bree, Adam J., Routh, Vanessa H., Kahn, Barbara B., Fisher, Simon J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319720/
https://ncbi.nlm.nih.gov/pubmed/27797912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0917
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