The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1α Levels and Colorectal Cancer Cell Survival under Hypoxia

Oxygen-dependent HIF1α hydroxylation and degradation are strictly controlled by PHD2. In hypoxia, HIF1α partly escapes degradation because of low oxygen availability. Here, we show that PHD2 is phosphorylated on serine 125 (S125) by the mechanistic target of rapamycin (mTOR) downstream kinase P70S6K...

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Publicado en:Cell Rep
Autores principales: Di Conza, Giusy, Trusso Cafarello, Sarah, Loroch, Stefan, Mennerich, Daniela, Deschoemaeker, Sofie, Di Matteo, Mario, Ehling, Manuel, Gevaert, Kris, Prenen, Hans, Zahedi, Rene Peiman, Sickmann, Albert, Kietzmann, Thomas, Moretti, Fabiola, Mazzone, Massimiliano
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318657/
https://ncbi.nlm.nih.gov/pubmed/28199842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.01.051
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