Pharmacokinetics of Standard- and Reduced-Dose Recombinant Human Soluble Thrombomodulin in Patients with Septic Disseminated Intravascular Coagulation during Continuous Hemodiafiltration

INTRODUCTION: Recombinant human soluble thrombomodulin (rTM) is reportedly excreted by the kidneys; therefore, the recommended dose for patients with renal impairment is one-third of the standard dose. The aim of this study was to evaluate whether this reduced dose of rTM achieves effective drug con...

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Publicado en:Front Med (Lausanne)
Main Authors: Watanabe, Eizo, Yamazaki, Shingo, Setoguchi, Daisuke, Sadahiro, Tomohito, Tateishi, Yoshihisa, Suzuki, Tatsuya, Ishii, Itsuko, Oda, Shigeto
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2017
Assuntos:
Medicine
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318446/
https://ncbi.nlm.nih.gov/pubmed/28271063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmed.2017.00015
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