Infection-derived lipids elicit an immune deficiency circuit in arthropods

The insect immune deficiency (IMD) pathway resembles the tumour necrosis factor receptor network in mammals and senses diaminopimelic-type peptidoglycans present in Gram-negative bacteria. Whether unidentified chemical moieties activate the IMD signalling cascade remains unknown. Here, we show that...

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發表在:Nat Commun
Main Authors: Shaw, Dana K., Wang, Xiaowei, Brown, Lindsey J., Chávez, Adela S. Oliva, Reif, Kathryn E., Smith, Alexis A., Scott, Alison J., McClure, Erin E., Boradia, Vishant M., Hammond, Holly L., Sundberg, Eric J., Snyder, Greg A., Liu, Lei, DePonte, Kathleen, Villar, Margarita, Ueti, Massaro W., de la Fuente, José, Ernst, Robert K., Pal, Utpal, Fikrig, Erol, Pedra, Joao H. F.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316886/
https://ncbi.nlm.nih.gov/pubmed/28195158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14401
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