Dynamic Contrast Enhanced-Magnetic Resonance Imaging as a Pharmacodynamic Biomarker for Pazopanib in Metastatic Renal Carcinoma

INTRODUCTION/BACKGROUND: Traditional imaging assessment criteria may not correlate well with clinical benefit from vascular endothelial growth factor pathway-directed therapy in metastatic renal cancer. Preclinical data suggest tumor growth is preceded by a rise in K(trans), a parameter derived from...

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Publicado no:Clin Genitourin Cancer
Main Authors: Sweis, Randy F., Medved, Milica, Towey, Shannon, Karczmar, Gregory S., Oto, Aytekin, Szmulewitz, Russell Z., O’Donnell, Peter H., Fishkin, Paul, Karrison, Theodore, Stadler, Walter M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315677/
https://ncbi.nlm.nih.gov/pubmed/27634566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clgc.2016.08.011
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