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Absence of Hikeshi, a nuclear transporter for heat-shock protein HSP70, causes infantile hypomyelinating leukoencephalopathy

Genetic leukoencephalopathies are a heterogeneous group of central nervous system disorders with white matter involvement. In a Finnish patient, we identified a novel homozygous disease-causing variant in HIKESHI, c.11G>C, p.(Cys4Ser), leading to hypomyelinating leukoencephalopathy with periventr...

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Detalhes bibliográficos
Publicado no:Eur J Hum Genet
Main Authors: Vasilescu, Catalina, Isohanni, Pirjo, Palomäki, Maarit, Pihko, Helena, Suomalainen, Anu, Carroll, Christopher J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315520/
https://ncbi.nlm.nih.gov/pubmed/28000699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2016.189
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