The targetable A1 Huntington disease haplotype has distinct Amerindian and European origins in Latin America

Huntington disease (HD) is a dominant neurodegenerative disorder caused by a CAG repeat expansion in the Huntingtin (HTT) gene. HD occurs worldwide, but the causative mutation is found on different HTT haplotypes in distinct ethnic groups. In Latin America, HD is thought to have European origins, bu...

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Publicat a:Eur J Hum Genet
Autors principals: Kay, Chris, Tirado-Hurtado, Indira, Cornejo-Olivas, Mario, Collins, Jennifer A, Wright, Galen, Inca-Martinez, Miguel, Veliz-Otani, Diego, Ketelaar, Maria E, Slama, Ramy A, Ross, Colin J, Mazzetti, Pilar, Hayden, Michael R
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315506/
https://ncbi.nlm.nih.gov/pubmed/28000697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2016.169
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