Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC Dependent Cell Death in T-Cell and Hodgkin Lymphoma

Proteasome regulated nuclear-factor kappa-B has been shown to be important for cell survival in T-cell lymphoma (TCL) and Hodgkin lymphoma (HL) models. Several new small molecule proteasome inhibitors are under various stages of active preclinical and clinical development. We completed a comprehensi...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Ravi, Dashnamoorthy, Beheshti, Afshin, Abermil, Nasséra, Passero, Frank, Sharma, Jaya, Coyle, Michael, Kritharis, Athena, Kandela, Irawati, Hlatky, Lynn, Sitkovsky, Michail V., Mazar, Andrew, Gartenhaus, Ronald B, Evens, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315412/
https://ncbi.nlm.nih.gov/pubmed/26988986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2477
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