Restoration of Nrf2 Signaling Normalizes the Regenerative Niche

Chronic hyperglycemia impairs intracellular redox homeostasis and contributes to impaired diabetic tissue regeneration. The Keap1/Nrf2 pathway is a critical regulator of the endogenous antioxidant response system, and its dysfunction has been implicated in numerous pathologies. Here we characterize...

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Vydáno v:Diabetes
Hlavní autoři: Soares, Marc A., Cohen, Oriana D., Low, Yee Cheng, Sartor, Rita A., Ellison, Trevor, Anil, Utkarsh, Anzai, Lavinia, Chang, Jessica B., Saadeh, Pierre B., Rabbani, Piul S., Ceradini, Daniel J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2016
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314719/
https://ncbi.nlm.nih.gov/pubmed/26647385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-0453
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