Palindromic amplification of the ERBB2 oncogene in primary HER2-positive breast tumors

Oncogene amplification confers a growth advantage to tumor cells for clonal expansion. There are several, recurrently amplified oncogenes throughout the human genome. However, it remains unclear whether this recurrent amplification is solely a manifestation of increased fitness resulting from random...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Marotta, Michael, Onodera, Taku, Johnson, Jeffrey, Budd, G. Thomas, Watanabe, Takaaki, Cui, Xiaojiang, Giuliano, Armando E., Niida, Atsushi, Tanaka, Hisashi
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314454/
https://ncbi.nlm.nih.gov/pubmed/28211519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41921
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