A retinoic acid-hedgehog cascade coordinates mesoderm-inducing signals and endoderm competence during lung specification

Organogenesis of the trachea and lungs requires a complex series of mesoderm-endoderm interactions mediated by WNT, BMP, retinoic acid (RA) and hedgehog (Hh), but how these pathways interact in a gene regulatory network is less clear. Using Xenopus embryology, mouse genetics, and human ES cell cultu...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Rankin, Scott A, Han, Lu, McCracken, Kyle W, Kenny, Alan P, Anglin, Christopher T, Grigg, Emily A, Crawford, Calyn M, Wells, James M, Shannon, John M, Zorn, Aaron M
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314425/
https://ncbi.nlm.nih.gov/pubmed/27320915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.060
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