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Hepatocyte-secreted extracellular vesicles modify blood metabolome and endothelial function by an arginase-dependent mechanism

Hepatocytes release extracellular vesicles (EVs) loaded with signaling molecules and enzymes into the bloodstream. Although the importance of EVs in the intercellular communication is already recognized, the metabolic impact of the enzymes carried by these vesicles is still unclear. We evaluated the...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Royo, Felix, Moreno, Laura, Mleczko, Justyna, Palomo, Laura, Gonzalez, Esperanza, Cabrera, Diana, Cogolludo, Angel, Vizcaino, Francisco Perez, van-Liempd, Sebastiaan, Falcon-Perez, Juan M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314384/
https://ncbi.nlm.nih.gov/pubmed/28211494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42798
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