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Focus on PNA Flexibility and RNA Binding using Molecular Dynamics and Metadynamics
Peptide Nucleic Acids (PNAs) can efficiently target DNA or RNA acting as chemical tools for gene regulation. Their backbone modification and functionalization is often used to increase the affinity for a particular sequence improving selectivity. The understanding of the trading forces that lead the...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5314342/ https://ncbi.nlm.nih.gov/pubmed/28211525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42799 |
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