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General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae

In eukaryotic cells, two conserved protein kinases, Gcn2 and TOR complex 1 (TORC1), couple amino acid conditions to protein translation. Gcn2 functions as an amino acid sensor and is activated by uncharged tRNAs that accumulate when intracellular amino acids are limited. Activated Gcn2 phosphorylate...

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書誌詳細
出版年:J Biol Chem
主要な著者: Yuan, Wenjie, Guo, Shuguang, Gao, Jiaoqi, Zhong, Mingming, Yan, Gonghong, Wu, Wangmeng, Chao, Yapeng, Jiang, Yu
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314164/
https://ncbi.nlm.nih.gov/pubmed/28057755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.772194
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