General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae

In eukaryotic cells, two conserved protein kinases, Gcn2 and TOR complex 1 (TORC1), couple amino acid conditions to protein translation. Gcn2 functions as an amino acid sensor and is activated by uncharged tRNAs that accumulate when intracellular amino acids are limited. Activated Gcn2 phosphorylate...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Yuan, Wenjie, Guo, Shuguang, Gao, Jiaoqi, Zhong, Mingming, Yan, Gonghong, Wu, Wangmeng, Chao, Yapeng, Jiang, Yu
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314164/
https://ncbi.nlm.nih.gov/pubmed/28057755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.772194
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