A Single Amino Acid Mutation Converts (R)-5-Diphosphomevalonate Decarboxylase into a Kinase

The biosynthesis of isopentenyl diphosphate, a fundamental precursor for isoprenoids, via the mevalonate pathway is completed by diphosphomevalonate decarboxylase. This enzyme catalyzes the formation of isopentenyl diphosphate through the ATP-dependent phosphorylation of the 3-hydroxyl group of (R)-...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Motoyama, Kento, Unno, Hideaki, Hattori, Ai, Takaoka, Tomohiro, Ishikita, Hiroshi, Kawaide, Hiroshi, Yoshimura, Tohru, Hemmi, Hisashi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Enzymology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5313113/
https://ncbi.nlm.nih.gov/pubmed/28003359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.752535
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