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CD40-mediated NFκB activation in B cells is increased in multiple sclerosis and modulated by therapeutics()

CD40 interacts with CD40 ligand and plays an essential role in immune regulation and homeostasis. Recent research findings, however, support a pathogenic role of CD40 in a number of autoimmune diseases. We previously showed that memory B cells from relapsing-remitting multiple sclerosis (RRMS) patie...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Chen, Ding, Ireland, Sara J., Remington, Gina, Alvarez, Enrique, Racke, Michael K., Greenberg, Benjamin, Frohman, Elliot M., Monson, Nancy L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312703/
https://ncbi.nlm.nih.gov/pubmed/27798157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600782
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