Metformin enhances TRAIL-induced apoptosis by Mcl-1 degradation via Mule in colorectal cancer cells

Metformin is an anti-diabetic drug with a promising anti-cancer potential. In this study, we show that subtoxic doses of metformin effectively sensitize human colorectal cancer (CRC) cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), which induces apoptosis. Metformin al...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Park, Seong Hye, Lee, Dae-Hee, Kim, Jung Lim, Kim, Bo Ram, Na, Yoo Jin, Jo, Min Jee, Jeong, Yoon A., Lee, Suk-Young, Lee, Sun Il, Lee, Yong Yook, Oh, Sang Cheul
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312327/
https://ncbi.nlm.nih.gov/pubmed/27517746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11147
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