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R-spondin 1 is required for specification of hematopoietic stem cells through Wnt16 and Vegfa signaling pathways

Hematopoietic stem cells (HSCs) are the therapeutic component of bone marrow transplants, but finding immune-compatible donors limits treatment availability and efficacy. Recapitulation of endogenous specification during development is a promising approach to directing HSC specification in vitro, bu...

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Dades bibliogràfiques
Publicat a:Development
Autors principals: Genthe, Jamie R., Clements, Wilson K.
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Ltd 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312032/
https://ncbi.nlm.nih.gov/pubmed/28087636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.139956
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