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R-spondin 1 is required for specification of hematopoietic stem cells through Wnt16 and Vegfa signaling pathways
Hematopoietic stem cells (HSCs) are the therapeutic component of bone marrow transplants, but finding immune-compatible donors limits treatment availability and efficacy. Recapitulation of endogenous specification during development is a promising approach to directing HSC specification in vitro, bu...
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| Publié dans: | Development |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Company of Biologists Ltd
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5312032/ https://ncbi.nlm.nih.gov/pubmed/28087636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.139956 |
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