Human immunodeficiency virus glycoprotein (gp120) infused into rat brain induces interleukin 1 to elevate pituitary-adrenal activity and decrease peripheral cellular immune responses.

Intracerebroventricular (i.c.v.) infusion of glycosylated recombinant gp120, the envelope protein of human immunodeficiency virus, in various doses (100 ng to 4 micrograms) resulted in detection of interleukin 1 (IL-1) activity in a high percentage (61%; 33 of 54) of rat brains, whereas IL-1 was ver...

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Detalhes bibliográficos
Main Authors: Sundar, S K, Cierpial, M A, Kamaraju, L S, Long, S, Hsieh, S, Lorenz, C, Aaron, M, Ritchie, J C, Weiss, J M
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC53111/
https://ncbi.nlm.nih.gov/pubmed/1662389
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