Targeting Angiotensin II Type-1 Receptor (AT(1)R) Inhibits the Harmful Phenotype of Plasmodium-Specific CD8(+) T Cells during Blood-Stage Malaria

CD8(+) T-cell response is critical in the pathogenesis of cerebral malaria during blood-stage. Our group and other have been shown that angiotensin II (Ang II) and its receptor AT(1) (AT(1)R), a key effector axis of renin-angiotensin system (RAS), have immune regulatory effects on T cells. Previousl...

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發表在:Front Cell Infect Microbiol
Main Authors: Silva-Filho, João L., Caruso-Neves, Celso, Pinheiro, Ana A. S.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2017
主題:
Microbiology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5311040/
https://ncbi.nlm.nih.gov/pubmed/28261571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2017.00042
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