Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis

Cancer-associated fibroblasts (CAF) remain a poorly characterized, heterogeneous cell population. Here we characterized two previously described tumor-promoting CAF sub-types, smooth muscle actin (SMA)-positive myofibroblasts and senescent fibroblasts, identifying a novel link between the two. Analy...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Mellone, Massimiliano, Hanley, Christopher J., Thirdborough, Steve, Mellows, Toby, Garcia, Edwin, Woo, Jeongmin, Tod, Joanne, Frampton, Steve, Jenei, Veronika, Moutasim, Karwan A., Kabir, Tasnuva D., Brennan, Peter A, Venturi, Giulia, Ford, Kirsty, Herranz, Nicolas, Lim, Kue Peng, Clarke, James, Lambert, Daniel W., Prime, Stephen S., Underwood, Timothy J., Vijayanand, Pandurangan, Eliceiri, Kevin W., Woelk, Christopher, King, Emma V., Gil, Jesus, Ottensmeier, Christian H., Thomas, Gareth J.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5310659/
https://ncbi.nlm.nih.gov/pubmed/27992856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101127
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