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Mechanism of Protein Kinase R Inhibition by Human Cytomegalovirus pTRS1
Double-stranded RNAs (dsRNA) produced during human cytomegalovirus (HCMV) infection activate the antiviral kinase protein kinase R (PKR), which potently inhibits virus replication. The HCMV pTRS1 and pIRS1 proteins antagonize PKR to promote HCMV protein synthesis and replication; however, the mechan...
Shranjeno v:
| izdano v: | J Virol |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5309967/ https://ncbi.nlm.nih.gov/pubmed/27974558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01574-16 |
| Oznake: |
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