Screening for Novel Small-Molecule Inhibitors Targeting the Assembly of Influenza Virus Polymerase Complex by a Bimolecular Luminescence Complementation-Based Reporter System

Influenza virus RNA-dependent RNA polymerase consists of three viral protein subunits: PA, PB1, and PB2. Protein-protein interactions (PPIs) of these subunits play pivotal roles in assembling the functional polymerase complex, which is essential for the replication and transcription of influenza vir...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Li, Chunfeng, Wang, Zining, Cao, Yang, Wang, Lulan, Ji, Jingyun, Chen, Zhigao, Deng, Tao, Jiang, Taijiao, Cheng, Genhong, Qin, F. Xiao-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309938/
https://ncbi.nlm.nih.gov/pubmed/28031371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02282-16
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