Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1)

Precursor mRNA (pre-mRNA) splicing is catalyzed by a large ribonucleoprotein complex known as the spliceosome. Numerous studies have indicated that aberrant splicing patterns or mutations in spliceosome components, including the splicing factor 3b subunit 1 (SF3B1), are associated with hallmark canc...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chung, Felicia Fei-Lei, Tan, Perry Faith Tze Ming, Raja, Vijay Joseph, Tan, Boon-Shing, Lim, Kuan-Hon, Kam, Toh-Seok, Hii, Ling-Wei, Tan, Si Hoey, See, Sze-Jia, Tan, Yuen-Fen, Wong, Li-Zhe, Yam, Wai Keat, Mai, Chun Wai, Bradshaw, Tracey D., Leong, Chee-Onn
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309811/
https://ncbi.nlm.nih.gov/pubmed/28198434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42504
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