Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress

Dynamic regulation of glucose flux between aerobic glycolysis and the pentose phosphate pathway (PPP) during epithelial–mesenchymal transition (EMT) is not well-understood. Here we show that Snail (SNAI1), a key transcriptional repressor of EMT, regulates glucose flux toward PPP, allowing cancer cel...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Kim, Nam Hee, Cha, Yong Hoon, Lee, Jueun, Lee, Seon-Hyeong, Yang, Ji Hye, Yun, Jun Seop, Cho, Eunae Sandra, Zhang, Xianglan, Nam, Miso, Kim, Nami, Yuk, Young-Su, Cha, So Young, Lee, Yoonmi, Ryu, Joo Kyung, Park, Sunghyouk, Cheong, Jae-Ho, Kang, Sang Won, Kim, Soo-Youl, Hwang, Geum-Sook, Yook, Jong In, Kim, Hyun Sil
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309788/
https://ncbi.nlm.nih.gov/pubmed/28176759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14374
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