Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress

Dynamic regulation of glucose flux between aerobic glycolysis and the pentose phosphate pathway (PPP) during epithelial–mesenchymal transition (EMT) is not well-understood. Here we show that Snail (SNAI1), a key transcriptional repressor of EMT, regulates glucose flux toward PPP, allowing cancer cel...

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Publicado en:Nat Commun
Main Authors: Kim, Nam Hee, Cha, Yong Hoon, Lee, Jueun, Lee, Seon-Hyeong, Yang, Ji Hye, Yun, Jun Seop, Cho, Eunae Sandra, Zhang, Xianglan, Nam, Miso, Kim, Nami, Yuk, Young-Su, Cha, So Young, Lee, Yoonmi, Ryu, Joo Kyung, Park, Sunghyouk, Cheong, Jae-Ho, Kang, Sang Won, Kim, Soo-Youl, Hwang, Geum-Sook, Yook, Jong In, Kim, Hyun Sil
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309788/
https://ncbi.nlm.nih.gov/pubmed/28176759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14374
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