A substrate-bound structure of cyanobacterial biliverdin reductase identifies stacked substrates as critical for activity

Biliverdin reductase catalyses the last step in haem degradation and produces the major lipophilic antioxidant bilirubin via reduction of biliverdin, using NAD(P)H as a cofactor. Despite the importance of biliverdin reductase in maintaining the redox balance, the molecular details of the reaction it...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Takao, Haruna, Hirabayashi, Kei, Nishigaya, Yuki, Kouriki, Haruna, Nakaniwa, Tetsuko, Hagiwara, Yoshinori, Harada, Jiro, Sato, Hideaki, Yamazaki, Toshimasa, Sakakibara, Yoichi, Suiko, Masahito, Asada, Yujiro, Takahashi, Yasuhiro, Yamamoto, Ken, Fukuyama, Keiichi, Sugishima, Masakazu, Wada, Kei
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309722/
https://ncbi.nlm.nih.gov/pubmed/28169272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14397
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