Nitric oxide and another potent vasodilator are formed from NG-hydroxy-L-arginine by cultured endothelial cells.

The hypothesis was investigated that NG-hydroxy-L-arginine (L-HOArg) is an intermediate in the biosynthesis of nitric oxide (.NO) from L-arginine (L-Arg) by the constitutive .NO synthase (NOS) present in endothelial cells (ECs). When infused through a column of bovine aortic ECs on beads, either L-H...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Zembowicz, A, Hecker, M, Macarthur, H, Sessa, W C, Vane, J R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53096/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1662386/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.24.11172
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