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Dual Roles of IL-27 in Cancer Biology and Immunotherapy
IL-27 is a pleiotropic two-chain cytokine, composed of EBI3 and IL-27p28 subunits, which is structurally related to both IL-12 and IL-6 cytokine families. IL-27 acts through a heterodimer receptor consisting of IL-27Rα (WSX1) and gp130 chains, which mediate signaling predominantly through STAT1 and...
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| Publicado no: | Mediators Inflamm |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Hindawi Publishing Corporation
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5309407/ https://ncbi.nlm.nih.gov/pubmed/28255204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/3958069 |
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