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Hypoxia inducible factors regulate the transcription of the sprouty2 gene and expression of the sprouty2 protein
Receptor Tyrosine Kinase (RTK) signaling plays a major role in tumorigenesis and normal development. Sprouty2 (Spry2) attenuates RTK signaling and inhibits processes such as angiogenesis, cell proliferation, migration and survival, which are all upregulated in tumors. Indeed in cancers of the liver,...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5308774/ https://ncbi.nlm.nih.gov/pubmed/28196140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171616 |
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