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Hypoxia inducible factors regulate the transcription of the sprouty2 gene and expression of the sprouty2 protein

Receptor Tyrosine Kinase (RTK) signaling plays a major role in tumorigenesis and normal development. Sprouty2 (Spry2) attenuates RTK signaling and inhibits processes such as angiogenesis, cell proliferation, migration and survival, which are all upregulated in tumors. Indeed in cancers of the liver,...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gao, Xianlong, Hicks, Kristin C., Neumann, Paul, Patel, Tarun B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308774/
https://ncbi.nlm.nih.gov/pubmed/28196140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171616
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