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Hypoxia inducible factors regulate the transcription of the sprouty2 gene and expression of the sprouty2 protein

Receptor Tyrosine Kinase (RTK) signaling plays a major role in tumorigenesis and normal development. Sprouty2 (Spry2) attenuates RTK signaling and inhibits processes such as angiogenesis, cell proliferation, migration and survival, which are all upregulated in tumors. Indeed in cancers of the liver,...

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Veröffentlicht in:PLoS One
Hauptverfasser: Gao, Xianlong, Hicks, Kristin C., Neumann, Paul, Patel, Tarun B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308774/
https://ncbi.nlm.nih.gov/pubmed/28196140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171616
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