Elevated O-GlcNAcylation promotes gastric cancer cells proliferation by modulating cell cycle related proteins and ERK 1/2 signaling

O-GlcNAc transferase (OGT) is the only enzyme in mammals that catalyzes the attachment of β-D-N-acetylglucosamine (GlcNAc) to serine or threonine residues of target proteins. Hyper-O-GlcNAcylation is becoming increasingly realized as a general feature of cancer and contributes to rapid proliferation...

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Publicat a:Oncotarget
Autors principals: Jiang, Mingzuo, Qiu, Zhaoyan, Zhang, Song, Fan, Xing, Cai, Xiqiang, Xu, Bing, Li, Xiaowei, Zhou, Jinfeng, Zhang, Xiangyuan, Chu, Yi, Wang, Weijie, Liang, Jie, Horvath, Tamas, Yang, Xiaoyong, Wu, Kaichun, Nie, Yongzhan, Fan, Daiming
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308659/
https://ncbi.nlm.nih.gov/pubmed/27542217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11359
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