Antibody redesign by chain shuffling from random combinatorial immunoglobulin libraries.
A number of experiments on the shuffling of heavy and light chains from antibodies of defined specificity for the transition-state analogue hapten nitrophenyl phosphonamidate are described. The experiments report on the promiscuity of heavy and light chains in binding antigen and the feasibility of...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1991
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53085/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1763028/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.24.11120 |
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