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Role of p38(alpha/beta) MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B

Lethal Toxin from Clostridium sordellii (TcsL), which is casually involved in the toxic shock syndrome and in gas gangrene, enters its target cells by receptor-mediated endocytosis. Inside the cell, TcsL mono-O-glucosylates and thereby inactivates Rac/Cdc42 and Ras subtype GTPases, resulting in acti...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Toxins (Basel)
Hauptverfasser: Schelle, Ilona, Bruening, Janina, Buetepage, Mareike, Genth, Harald
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308236/
https://ncbi.nlm.nih.gov/pubmed/28025502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins9010002
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