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Intraluminal Tranexamic Acid Inhibits Intestinal Sheddases and Mitigates Gut and Lung Injury and Inflammation in a Rodent Model of Hemorrhagic Shock

BACKGROUND: Intravenous tranexamic acid (TXA) is an effective adjunct after hemorrhagic shock (HS) due to its antifibrinolytic properties. TXA is also a serine protease inhibitor and recent laboratory data demonstrated that intraluminal TXA into the small bowel inhibited digestive proteases and prot...

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Detalhes bibliográficos
Publicado no:J Trauma Acute Care Surg
Main Authors: Peng, Zhanglong, Ban, Kechen, LeBlanc, Anthony, Kozar, Rosemary Ann
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308205/
https://ncbi.nlm.nih.gov/pubmed/27027557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TA.0000000000001056
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