Rapid eradication of colon carcinoma by Clostridium perfringens Enterotoxin suicidal gene therapy

BACKGROUND: Bacterial toxins have evolved to an effective therapeutic option for cancer therapy. The Clostridium perfringens enterotoxin (CPE) is a pore-forming toxin with selective cytotoxicity. The transmembrane tight junction proteins claudin-3 and -4 are known high affinity CPE receptors. Their...

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Bibliographic Details
Published in:BMC Cancer
Main Authors: Pahle, Jessica, Menzel, Lutz, Niesler, Nicole, Kobelt, Dennis, Aumann, Jutta, Rivera, Maria, Walther, Wolfgang
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5307849/
https://ncbi.nlm.nih.gov/pubmed/28193196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3123-x
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