First insight into the somatic mutation burden of neurofibromatosis type 2-associated grade I and grade II meningiomas: a case report comprehensive genomic study of two cranial meningiomas with vastly different clinical presentation

BACKGROUND: Neurofibromatosis type 2 (NF2) is a rare autosomal dominant nervous system tumor predisposition disorder caused by constitutive inactivation of one of the two copies of NF2. Meningiomas affect about one half of NF2 patients, and are associated with a higher disease burden. Currently, the...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Dewan, Ramita, Pemov, Alexander, Dutra, Amalia S., Pak, Evgenia D., Edwards, Nancy A., Ray-Chaudhury, Abhik, Hansen, Nancy F., Chandrasekharappa, Settara C., Mullikin, James C., Asthagiri, Ashok R., Heiss, John D., Stewart, Douglas R., Germanwala, Anand V.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5307647/
https://ncbi.nlm.nih.gov/pubmed/28193203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3127-6
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